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Analyzing a dipeptide library to identify human dipeptidyl peptidase IV inhibitor

Human dipeptidyl peptidase IV (hDPPIV) inhibitors provide an effective strategy for the treatment of type 2 diabetes. Because certain peptides are known to act as hDPPIV inhibitors, a dataset of possible peptides with their inhibition intensities will facilitate the development of functional food for type 2 diabetes.

 A research in the Graduate Division of Nutritional and Environmental Sciences examined a total of 337 dipeptides with respect to their hDPPIV inhibitory effects. They have found that amino acid residues at N-termini dominated their inhibition intensities. Particularly highly inhibitory dipeptides discovered included the following novel dipeptides: Thr-His, Asn-His, Val-Leu, Met-Leu, and Met-Met. Using their dataset, prime candidates contributing to the hDPPIV inhibitory effect of soy protein hydrolyzates were successfully identified. This research helps us to find out possible dietary proteins that are potentially able to produce particularly highly hDPPIV inhibitory peptides.

This research was financially supported by FUJI OIL Co. Ltd.

Lan V.T.T., Ito K., Ohno M., Motoyama T., Ito S. and Kawarasaki Y.: Analyzing a dipeptide library to identify human dipeptidyl peptidase IV inhibitor. Food Chem. 175, 66-73 (2015) 

Biomelecular Engineering Lab.


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