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Microbiology

Molecular Characterization of Probiotic Bacteria and Infectious Pathogens

Research into health-promoting probiotics and health-damaging bacterial pathogens of foodborne and tickborne origins

Microbes are found in tremendous numbers everywhere in nature. Among these, there are microbes that are good for human health, and those that are bad for it. In our laboratory, we focus on lactic acid-producing bacteria that are good for human health, and on bacterial pathogens of foodborne and tickborne origins causing emerging infectious diseases that are bad for human health. Additionally, we analyze the function of prebiotic food through the change of intestinal environments.


1. Characterization of lactic acid-producing bacteria isolated from plant-fermented foods to develop new probiotic and functional foods
2. Molecular characterization of antibiotic-resistant bacteria isolated from food-producing animals, and molecular mechanisms of intracellular or intestinal infectious pathogens (foodborne infection)
3. Molecular epidemiology of bacterial pathogens, especially obligatory intracellular parasites transmitted by ticks, and the analysis of the pathogenic mechanisms of such bacteria (tickborne infection)
4. Analysis of role of prebiotic food through the alteration of intestinal microbiota

Professor

Norio OhashiPhD, Prof.
ohashi@u-shizuoka-ken.ac.jp
TEL.+81-54-264-5553

Details are here

http://sfns.u-shizuoka-ken.ac.jp/microbiol/

 

Figure.1

Adhesion of a new probiotic bacterial candidate to the Caco-2 human colonic carcinoma cell line used as a model of epithelial cells on intestine

Figure.2

THP-1 human acute leukemia cell line infected with an obligatory intracellular parasite, Anaplasma phagocytophilum (3-D imaging) Red arrow: intracellular inclusion of live Anaplasma bacteria Yellow arrow: THP-1 host cell nucleus

Reference

  1. Diagn Microbiol Infect Dis. pii: S0732-8893(19)30237-8 (2019)
  2. Jpn J Infect Dis. 72, 199-202 (2019)
  3. Jpn J Infect Dis. 72, 73-80 (2019)
  4. Emerg Infect Dis. 24, 2105-2107 (2018)
  5. FEMS Microbiol Lett. 364(6) (2017)
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