研究業績

2019年

[原著論文]

Shogo Nakano1*, Yuki Minamino1, Fumihito Hasabe, Sohei Ito*, Deracemization and Stereoinversion to Aromatic D-Amino Acid Derivatives with Ancestral L-Amino Acid Oxidase, ACS Catalysis, Just accepted, DOI:10.1021/acscatal.9b03418, 1: Equally contribution, *: Corresponding Author

・Shoya Yamada, Mayu Kawasaki, Michiko Fujihara, Masaki Watanabe, Yuta Takamura, Maho Takioku, Hiromi Nishioka, Yasuo Takeuchi, Makoto Makishima, Tomoharu Motoyama, Sohei Ito, Hiroaki Tokiwa, Shogo Nakano*, Hiroki Kakuta*, Competitive Binding Assay with an Umbelliferone-based Fluorescent Rexinoid for Retinoid X Receptor Ligand Screening, Journal of Medicinal Chemistry, in press, doi: 10.1021/acs.jmedchem.9b00995 *: Corresponding Author

・Muguruma Kyohei, Fujita Konomi, Fukuda Akane, Kishimoto Satoshi, Sakamoto Soichiro, Arima Risako, Ito Mayu, Kawasaki Mayu, Nakano Shogo, Ito Sohei, Shimizu Kanade, Taguchi Akihiro, Takayama Kentaro, Taniguchi Atsuhiko, Ito Yuji, Hayashi Yoshio*, Kinetics-based structural requirements of human immunoglobulin G binding peptides, ACS Omega, 4(11): 14390-14397

Shogo Nakano1*, Masazumi Niwa1, Yasuhisa Asano, Sohei Ito, Following the Evolutionary Track of a Highly Specific L-Arginine Oxidase by Reconstruction and Biochemical Analysis of Ancestral and Native Enzymes, Applied and Environmental Microbiology, 85(12), pii: e00459-19, DOI: 10.1128/AEM.00459-19, 1: Equally contribution, *: Corresponding Author

・Takaki Tokiwa1, Shogo Nakano1*, Yuta Yamamoto, Takeshi Ishikawa, Sohei Ito, Vladimir Sladek, Kaori Fukuzawa, Yuji Mochizuki, Hiroaki Tokiwa*, Fuminori Misaizu, and Yasuteru Shigeta*, Development of analysis toolkit to visualize interaction energies generated by fragment molecular orbital calculations, Journal of Chemical Information and Modeling, 59, 25-30, 1: Equally contribution, *: Corresponding Author
・Yurina Miyashita, Nobutaka Numoto, Sundaram Arulmozhiraja, Shogo Nakano, Naoya Matsuo, Kanade Shimizu, Osamu Shibahara, Michiko Fujihara, Hiroki Kakuta, Sohei Ito, Teikichi Ikura, Nobutoshi Ito and Hiroaki Tokiwa, Dual conformation of the ligand induces the partial agonistic activity of retinoid X receptor alpha, FEBS Lett., 593, 242-250.


2018年

[原著論文]

・Hashidume T, Sakano T, Mochizuki A, Ito K, Ito S, Kawarasaki Y, Miyoshi N. Identification of soybean peptide leginsulin variants in different cultivars and their insulin-like activities. Scientific Reports, 8(1): 16847, doi: 10.1038/s41598-018-35331-5

・Yuki Honda1, Shogo Nakano1, Sohei Ito, Mohammad Dadashipour, Zilian Zhang, Yutaka Kawarabayasi*, “Improvement of ST0452 GlcNAc-1-phosphate uridyltransferase activity by the cooperative effect of two single mutations identified through structure-based protein engineering”, Applied and Environmental Microbiology, 84, pii: e02213-18, 1Equally contribution

Shogo Nakano*, Tomoharu Motoyama, Yurina Miyashita, Yuki Ishizuka, Naoya Matsuo, Hiroaki Tokiwa, Suguru Shinoda, Yasuhisa Asano, and Sohei Ito, Benchmark analysis of native and artificial NAD+-dependent enzymes generated by a sequence based design method with or without phylogenetic data, Biochemistry,57, 3722-3732, DOI: 10.1021/acs.biochem.8b00339

・Akira Tani, Takuo Ohno, Tasuku Saito Sohei Ito, Tetsushi Yonekura, and Makoto Miwa, Effects of ozone on isoprene emission from two major Quercus species native to East Asia. J. Agri. Meteo., 73, 4, 195-202

・Yuko Shimamura, Mio Utsumi, Chikako Hirai, Shogo Nakano, Sohei Ito, Ai Tsuji, Takeshi Ishii, Takahiro Hosoya, Toshiyuki Kan, Norio Ohashi and Shuichi Masuda, Binding of Catechins to Staphylococcal Enterotoxin A, Molecules, 23(5), 1125, https://doi.org/10.3390/molecules23051125

[英文総説]

・Koichi Saeki, Sumio Hayakawa, Shogo Nakano, Sohei Ito, Yumiko Oishi, Yasuo Suzuki and Mamoru Isemura, “In Vitro and In Silico Studies of the Molecular Interactions of Epigallocatechin-3-O-gallate (EGCG) with Proteins That Explain the Health Benefits of Green Tea”, Molecules, 23, 1295

Shogo Nakano, Shin-ichi Megro, Tadashi Hase, Takuji Suzuki, Mamoru Isemura*, Yoriyuki Nakamura and Sohei Ito, “Computational Molecular Docking and X-ray Crystallographic Studies of Catechins in New Drug Design Strategies”, Molecules, 23, 2020

[日本語総説]

中野 祥吾, 新規アミノ酸配列解析手法の開発とタンパク質工学への応用, 生物工学会誌 特集 (日本生物工学会), 96, 573-577

・松井大亮、中野祥吾、Mohammad Dadashipour、浅野泰久 ,タンパク質の二次構造とアミノ酸の疎水性度に基づいた凝集に関連するホットスポットの合理的同定法, 酵素工学ニュース 第80号, 10

[特許]

・特願2018-93399、隅田泰生 常盤広明 伊藤創平 中野祥吾 新地浩之、”糖鎖結合性一本鎖抗体の改変”

[学会発表]

Shogo Nakano, Filling a gap between computational and experimental researches through sequence-based protein design, The 4th International Conference on Pharma and Food (ICPF) 2018, Shizuoka, Shizuoka, Japan (招待講演)

中野 祥吾 “新規アミノ酸配列解析手法、INTMSAlign の開発と応用”, 日本薬学会大会、3/27, 2018, 金沢市, 石川 (シンポジウム, 招待講演)


過去の業績はこちら