HOME>Laboratory>GPFNS02 >Clinical Nutrition and Management

Clinical Nutrition and Management

  • account_circleHidekazu AraiPhD, RD, Prof.
  • account_circleYuka KawakamiPhD, Research Asst. Prof.
Searching for nutritional management methods and food compositions that can contribute to the prevention / treatment of disease
Understand the metabolism of sick and healthy people, and explore "true nutritional status"
"Nutritional management" is extremely important in prolonging healthy life span and treating diseases. Currently, this laboratory focuses on the evaluation of “diet composition” and “functional nutrient” for treatment and prevention of ectopic fats such as fatty liver, especially “postprandial” metabolic dynamics, differences in nutrient utilization and biological responses (including molecular mechanism). In addition, hyperphosphatemia has been reported to induce vascular dysfunction not only in dialysis patients but also in healthy people, and it is necessary to accurately grasp phosphorus intake. Using a 24-hour urine collection method, we are examining the contents of diets that are useful for grasping phosphorus intake and nutritional management. Furthermore, because there is insufficient evidence about the effects of nutritional guidance, research is being conducted at hospitals where joint research is conducted on teaching methods and management methods. With regard to knowledge and techniques that are useful in the clinical field, thinking power and practical ability, we are engaged in the training of high quality managed dietitians with "research ability" through research.
1. Research on evaluating micronutrient intake and validity using 24-hour urine storage methods

To evaluate the latent deficiency of minerals and vitamins in the living body, "biological utilization (metabolism)", we are constructing a method that can grasp the nutritional status using the 24-hour urine storage method. Currently, we carry out clinical research, such as evaluation of nutritional indicators through dietary tests.

2. Research on establishment of suitable dietary therapy for hyperuricemia patients

Hyperuricemia is involved in the development of gout attacks and kidney disease and is increasing in young people. However, since the effectiveness of dietary therapy and the identification and mechanism of functional components that promote uric acid excretion have not been elucidated, we are conducting research with the aim of building nutritional evidence for uric acid metabolism.

3. Research on establishment of suitable dietary therapy for hyperlipidemia patients

Diet is extremely important in the treatment of dyslipidemia, but the effectiveness of nutritional guidance has not been fully evaluated. Therefore, we are conducting joint research with clinics with the aim of establishing effective nutritional guidance methods based on scientific evidence.

Figure 1
Correlation between dietary record and 24-h urine collection. Correlation between dietary record (DR) and 24-h urine collection (UC) for protein (A) and phosphorus (Pi) (B).
Figure 2
Change in serum TG levels by counseling for 12 months in the dietary and combined drug treatment groups. Red triangle, dietary counseling alone group (n=47); Blue circle, combined drug treatment group (n=12).
  1. J Nutr Sci Vitaminol 69(1):7-13 (2023)
  2. J Nutr Sci Vitaminol 69(1):21-27 (2023)
  3. J Clin Biochem Nutr.72(1):61-67 (2023)
  4. Clin Rheumatol. 40(7):2881-2888 (2021)
  5. Nutrition. 85:111128 (2021)
  6. J Clin Biochem Nutr. 68(1):78-85 (2021)
  7. Nutrition. 72:110694 (2020)
  8. J Atheroscler Thromb. 26(1):39-49 (2019)