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最新の論文

2021.01.29 内田准教授の論文が掲載されました。

『Involvement of pore helix in voltage-dependent inactivation of TRPM5 channel』
Kunitoshi Uchida, Tomo Kita, Mitsutoki Hatta, Satoru G. Itoh, Hisashi Okumura, Makoto Tominaga, Jun Yamazaki
Heliyon. 2021 Jan 29;7(1):e06102.

▼ doi: 10.1016/j.heliyon.2021.e06102

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2020.7 弘前大学川端先生との共同研究の論文が受理されました。

『Intragastric administration of AMG517, a TRPV1 antagonist, enhanced activity-dependent energy metabolism via capsaicin-sensitive sensory nerves in mice』
Jun Hai, Fuminori Kawabata, Kunitoshi Uchida, Shotaro Nishimura, Shoji Tabata
echnol Biochem. 2020 Oct;84(10):2121-2127.

▼ doi: 10.1080/09168451.2020.1789836. Epub 2020 Jul 7.

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これまでの論文

『Identification and classification of a new TRPM3 variant (γ subtype)』
Uchida K, Fukuta N, Yamazaki J, Tominaga M.
J Physiol Sci. 2019 Jul;69(4):623-634.

▼doi: 10.1007/s12576-019-00677-6. Epub 2019 Apr 22. PMID: 31011981

『FK506 (tacrolimus) causes pain sensation through the activation of transient receptor potential ankyrin 1 (TRPA1) channels』
Kita T, Uchida K, Kato K, Suzuki Y, Tominaga M, Yamazaki J.
J Physiol Sci. 2019 Mar;69(2):305-316.

▼doi: 10.1007/s12576-018-0647-z. Epub 2018 Nov 26. PMID: 30478741

『Sensory nerve supports epithelial stem cell function in healing of corneal epithelium in mice: the role of trigeminal nerve transient receptor potential vanilloid 4』
Okada Y, Sumioka T, Ichikawa K, Sano H, Nambu A, Kobayashi K, Uchida K, Suzuki Y, Tominaga M, Reinach PS, Hirai SI, Jester JV, Miyajima M, Shirai K, Iwanishi H, Kao WW, Liu CY, Saika S.
Lab Invest. 2019 Feb;99(2):210-230.

▼doi: 10.1038/s41374-018-0118-4. Epub 2018 Nov 9. PMID: 30413814

『Involvement of VNUT-exocytosis in transient receptor potential vanilloid 4-dependent ATP release from gastrointestinal epithelium』
Mihara H, Uchida K, Koizumi S, Moriyama Y.
PLoS One. 2018 Oct 26;13(10):e0206276.

▼doi: 10.1371/journal.pone.0206276. eCollection 2018. PMID: 30365528

『Role of thermo-sensitive transient receptor potential channels in brown adipose Ttssue』
Uchida K, Sun W, Yamazaki J, Tominaga M.
Biol Pharm Bull. 2018;41(8):1135-1144.

▼doi: 10.1248/bpb.b18-00063. PMID: 30068861

『TRPV2 channel inhibitors attenuate fibroblast differentiation and contraction mediated by keratinocyte-derived TGF-β1 in an in vitro wound healing model of rats』
Ishii T, Uchida K, Hata S, Hatta M, Kita T, Miyake Y, Okamura K, Tamaoki S, Ishikawa H, Yamazaki J.
J Dermatol Sci. 2018 Jun;90(3):332-342.

▼doi: 10.1016/j.jdermsci.2018.03.003. Epub 2018 Mar 6. PMID: 29610016

『Keratin 13 gene is epigenetically suppressed during transforming growth factor-β1-induced epithelial-mesenchymal transition in a human keratinocyte cell line』
Hatta M, Miyake Y, Uchida K, Yamazaki J.
Biochem Biophys Res Commun. 2018 Feb 5;496(2):381-386.

▼doi: 10.1016/j.bbrc.2018.01.047. Epub 2018 Jan 8. PMID: 29326042

『β-Eudesmol, an oxygenized sesquiterpene, stimulates appetite via TRPA1 and the autonomic nervous system』
Ohara K, Fukuda T, Ishida Y, Takahashi C, Ohya R, Katayama M, Uchida K, Tominaga M, Nagai K.
Sci Rep. 2017 Nov 17;7(1):15785.

▼doi: 10.1038/s41598-017-16150-6. PMID: 29150643

『Mouse Anaphylactic Hypotension Is Characterized by Initial Baroreflex Independent Renal Sympathoinhibition Followed by Sustained Renal Sympathoexcitation』
Zhang T, Tanida M, Uchida K, Suzuki Y, Yang W, Kuda Y, Kurata Y, Tominaga M, Shibamoto T.
Front Physiol. 2017 Sep 7;8:669.

▼doi: 10.3389/fphys.2017.00669. eCollection 2017. PMID: 28936180

『10-oxo-12( Z)-octadecenoic acid, a linoleic acid metabolite produced by gut lactic acid bacteria, enhances energy metabolism by activation of TRPV1』
Kim M, Furuzono T, Yamakuni K, Li Y, Kim YI, Takahashi H, Ohue-Kitano R, Jheng HF, Takahashi N, Kano Y, Yu R, Kishino S, Ogawa J, Uchida K, Yamazaki J, Tominaga M, Kawada T, Goto T.
FASEB J. 2017 Nov;31(11):5036-5048.

▼ddoi: 10.1096/fj.201700151R. Epub 2017 Jul 28. PMID: 28754711

『l-Ornithine and l-lysine stimulate gastrointestinal motility via transient receptor potential vanilloid 1』
Nakato J, Ho YY, Omae R, Mizushige T, Uchida K, Tominaga M, Kim M, Goto T, Takahashi N, Kawada T, Akiduki S, Kanamoto R, Ohinata K.
Mol Nutr Food Res. 2017 Nov;61(11).

▼doi: 10.1002/mnfr.201700230. Epub 2017 Sep 7. PMID: 28722259

『Involvement of thermosensitive TRP channels in energy metabolism』
Uchida K, Dezaki K, Yoneshiro T, Watanabe T, Yamazaki J, Saito M, Yada T, Tominaga M, Iwasaki Y.
J Physiol Sci. 2017 Sep;67(5):549-560.

▼doi: 10.1007/s12576-017-0552-x. Epub 2017 Jun 27. PMID: 28656459

『Hypotonicity-induced cell swelling activates TRPA1』
Fujita F, Uchida K, Takayama Y, Suzuki Y, Takaishi M, Tominaga M.
J Physiol Sci. 2018 Jul;68(4):431-440.

▼doi: 10.1007/s12576-017-0545-9. Epub 2017 Jun 16. PMID: 28623463

『Biphasic renal sympathetic response to hemorrhagic hypotension in mice』
Zhang T, Tanida M, Uchida K, Suzuki Y, Yang W, Kuda Y, Kurata Y, Tominaga M, Shibamoto T.
Shock. 2017 Nov;48(5):576-582.

▼doi: 10.1097/SHK.0000000000000889. PMID: 28459715

『Lysophosphatidic acid-induced itch is mediated by signalling of LPA 5 receptor, phospholipase D and TRPA1/TRPV1』
Kittaka H, Uchida K, Fukuta N, Tominaga M.
J Physiol. 2017 Apr 15;595(8):2681-2698.

▼doi: 10.1113/JP273961. Epub 2017 Mar 22. PMID: 28176353

『TRPV2 regulates BAT thermogenesis and differentiation』
Sun W, Uchida K, Tominaga M.
Channels (Austin). 2017 Mar 4;11(2):94-96.

▼doi: 10.1080/19336950.2016.1228401. Epub 2016 Aug 29. PMID: 27573536

『Activation of TRPV2 negatively regulates the differentiation of mouse brown adipocytes』
Sun W, Uchida K, Takahashi N, Iwata Y, Wakabayashi S, Goto T, Kawada T, Tominaga M.
Pflugers Arch. 2016 Sep;468(9):1527-40.

▼doi: 10.1007/s00424-016-1846-1. Epub 2016 Jun 18. PMID: 27318696

『TRPM3 gating in planar lipid bilayers defines peculiar agonist specificity』
Demirkhanyan L, Uchida K, Tominaga M, Zakharian E.
Channels (Austin). 2016 Jul 3;10(4):258-60.

▼doi: 10.1080/19336950.2016.1155900. Epub 2016 Feb 22. PMID: 26901668

『Lack of TRPV2 impairs thermogenesis in mouse brown adipose tissue』
Sun W, Uchida K, Suzuki Y, Zhou Y, Kim M, Takayama Y, Takahashi N, Goto T, Wakabayashi S, Kawada T, Iwata Y, Tominaga M.
EMBO Rep. 2016 Mar;17(3):383-99.

▼doi: 10.15252/embr.201540819. Epub 2016 Feb 11. PMID: 26882545

『Fish oil intake induces UCP1 upregulation in brown and white adipose tissue via the sympathetic nervous system』
Kim M, Goto T, Yu R, Uchida K, Tominaga M, Kano Y, Takahashi N, Kawada T.
Sci Rep. 2015 Dec 17;5:18013.

▼doi: 10.1038/srep18013. PMID: 26673120

『Stimulation-dependent gating of TRPM3 channel in planar lipid bilayers』
Uchida K, Demirkhanyan L, Asuthkar S, Cohen A, Tominaga M, Zakharian E.
FASEB J. 2016 Mar;30(3):1306-16.

▼doi: 10.1096/fj.15-281576. Epub 2015 Dec 9. PMID: 26655382

『Reciprocal effects of capsaicin and menthol on thermosensation through regulated activities of TRPV1 and TRPM8』
Takaishi M, Uchida K, Suzuki Y, Matsui H, Shimada T, Fujita F, Tominaga M.
J Physiol Sci. 2016 Mar;66(2):143-55.

▼doi: 10.1096/fj.15-281576. Epub 2015 Dec 9. PMID: 26645885

『TRPM7 protein contributes to intercellular junction formation in mouse urothelium』
Watanabe M, Suzuki Y, Uchida K, Miyazaki N, Murata K, Matsumoto S, Kakizaki H, Tominaga M.
J Biol Chem. 2015 Dec 11;290(50):29882-92.

▼doi: 10.1074/jbc.M115.667899. Epub 2015 Oct 26. PMID: 26504086

『TRPM2, a susceptibility gene for bipolar disorder, regulates glycogen synthase kinase-3 activity in the brain』
Jang Y, Lee SH, Lee B, Jung S, Khalid A, Uchida K, Tominaga M, Jeon D, Oh U.
J Neurosci. 2015 Aug 26;35(34):11811-23.

▼doi: 10.1523/JNEUROSCI.5251-14.2015. PMID: 26311765

『Identification of significant amino acids in multiple transmembrane domains of human transient receptor potential ankyrin 1 (TRPA1) for activation by eudesmol, an oxygenized sesquiterpene in hop essential oil』
Ohara K, Fukuda T, Okada H, Kitao S, Ishida Y, Kato K, Takahashi C, Katayama M, Uchida K, Tominaga M.
J Biol Chem. 2015 Jan 30;290(5):3161-71.

▼doi: 10.1074/jbc.M114.600932. Epub 2014 Dec 18. PMID: 25525269

『The role of TRPM2 in pancreatic β-cells and the development of diabetes』
Uchida K, Tominaga M.
Cell Calcium. 2014 Nov;56(5):332-9.

▼doi: 10.1016/j.ceca.2014.07.001. Epub 2014 Jul 18. PMID: 25084624

『Involvement of cAMP/EPAC/TRPM2 activation in glucose- and incretin-induced insulin secretion』
Yosida M, Dezaki K, Uchida K, Kodera S, Lam NV, Ito K, Rita RS, Yamada H, Shimomura K, Ishikawa SE, Sugawara H, Kawakami M, Tominaga M, Yada T, Kakei M.
Diabetes. 2014 Oct;63(10):3394-403.

▼doi: 10.2337/db13-1868. Epub 2014 May 13. PMID: 24824430

『Activation and inhibition of thermosensitive TRP channels by voacangine, an alkaloid present in Voacanga africana, an African tree』
Yamawaki H, Mihara H, Suzuki N, Nishizono H, Uchida K, Watanabe S, Tominaga M, Sugiyama T.
Am J Physiol Gastrointest Liver Physiol. 2014 Jul 1;307(1):G33-40.

▼doi: 10.1021/np400885u. Epub 2014 Jan 31. PMID: 24484240

『Role of transient receptor potential vanilloid 4 activation in indomethacin-induced intestinal damage』
Terada Y, Horie S, Takayama H, Uchida K, Tominaga M, Watanabe T.
J Nat Prod. 2014 Feb 28;77(2):285-97.

▼doi: 10.1152/ajpgi.00105.2013. Epub 2014 May 1. PMID: 24789205

『Inhibitory effects of monoterpenes on human TRPA1 and the structural basis of their activity』
Takaishi M, Uchida K, Fujita F, Tominaga M.
J Physiol Sci. 2014 Jan;64(1):47-57.

▼doi: 10.1007/s12576-013-0289-0. PMID: 24122170

『Identification of a splice variant of mouse TRPA1 that regulates TRPA1 activity』
Zhou Y, Suzuki Y, Uchida K, Tominaga M.
Nat Commun. 2013;4:2399.

▼doi: 10.1038/ncomms3399. PMID: 24008932

『Extracellular zinc ion regulates transient receptor potential melastatin 5 (TRPM5) channel activation through its interaction with a pore loop domain』
Uchida K, Tominaga M.
J Biol Chem. 2013 Sep 6;288(36):25950-5.

▼doi: 10.1074/jbc.M113.470138. Epub 2013 Jul 24. PMID: 23884414

『Ambient temperature affects the temperature threshold for TRPM8 activation through interaction of phosphatidylinositol 4,5-bisphosphate』
Fujita F, Uchida K, Takaishi M, Sokabe T, Tominaga M.
J Neurosci. 2013 Apr 3;33(14):6154-9.

▼doi: 10.1523/JNEUROSCI.5672-12.2013. PMID: 23554496

『Involvement of TRPA1 activation in acute pain induced by cadmium in mice』
Miura S, Takahashi K, Imagawa T, Uchida K, Saito S, Tominaga M, Ohta T.
Mol Pain. 2013 Feb 28;9:7.

▼doi: 10.1186/1744-8069-9-7. PMID: 23448290

『TRPM2 contributes to antigen-stimulated Ca?? influx in mucosal mast cells』
Oda S, Uchida K, Wang X, Lee J, Shimada Y, Tominaga M, Kadowaki M.
Pflugers Arch. 2013 Jul;465(7):1023-30.

▼doi: 10.1007/s00424-013-1219-y. Epub 2013 Jan 31. PMID: 23371039

『1,8-cineole, a TRPM8 agonist, is a novel natural antagonist of human TRPA1』
Takaishi M, Fujita F, Uchida K, Yamamoto S, Sawada Shimizu M, Hatai Uotsu C, Shimizu M, Tominaga M.
Mol Pain. 2012 Nov 29;8:86.

▼doi: 10.1186/1744-8069-8-86. PMID: 23192000

『Isothiocyanates from Wasabia japonica activate transient receptor potential ankyrin 1 channel』
Uchida K, Miura Y, Nagai M, Tominaga M.
Chem Senses. 2012 Nov;37(9):809-18.

▼doi: 10.1093/chemse/bjs065. Epub 2012 Aug 6. PMID: 22869685

『Primary alcohols activate human TRPA1 channel in a carbon chain length-dependent manner』
Komatsu T, Uchida K, Fujita F, Zhou Y, Tominaga M.
Pflugers Arch. 2012 Apr;463(4):549-59.

▼doi: 10.1007/s00424-011-1069-4. Epub 2012 Jan 6. PMID: 22222967

『Activation of transient receptor potential A1 by a non-pungent capsaicin-like compound, capsiate』
Shintaku K, Uchida K, Suzuki Y, Zhou Y, Fushiki T, Watanabe T, Yazawa S, Tominaga M.
Br J Pharmacol. 2012 Mar;165(5):1476-86.

▼doi: 10.1111/j.1476-5381.2011.01634.x. PMID: 21883144

『The role of thermosensitive TRP (transient receptor potential) channels in insulin secretion』
Uchida K, Tominaga M.
Endocr J. 2011;58(12):1021-8.

▼doi: 10.1507/endocrj.ej11-0130. Epub 2011 Jul 23. PMID: 21785227

『TRPM2 modulates insulin secretion in pancreatic β-cells』
Uchida K, Tominaga M.
Islets. Jul-Aug 2011;3(4):209-11.

▼doi: 10.4161/isl.3.4.16130. Epub 2011 Jul 1. PMID: 21636972

『Hypoxia-induced sensitization of transient receptor potential vanilloid 1 involves activation of hypoxia-inducible factor-1 alpha and PKC』
Ristoiu V, Shibasaki K, Uchida K, Zhou Y, Ton BH, Flonta ML, Tominaga M.
Pain. 2011 Apr;152(4):936-45.

▼doi: 10.1016/j.pain.2011.02.024. Epub 2011 Mar 4. PMID: 21376466

『Unusual pungency from extra-virgin olive oil is attributable to restricted spatial expression of the receptor of oleocanthal』
Peyrot des Gachons C, Uchida K, Bryant B, Shima A, Sperry JB, Dankulich-Nagrudny L, Tominaga M, Smith AB 3rd, Beauchamp GK, Breslin PA.
J Neurosci. 2011 Jan 19;31(3):999-1009.

▼doi: 10.1523/JNEUROSCI.1374-10.2011. PMID: 21248124

『Lack of TRPM2 impaired insulin secretion and glucose metabolisms in mice』
Uchida K, Dezaki K, Damdindorj B, Inada H, Shiuchi T, Mori Y, Yada T, Minokoshi Y, Tominaga M.
Diabetes. 2011 Jan;60(1):119-26.

▼doi: 10.2337/db10-0276. Epub 2010 Oct 4. PMID: 20921208

『Activation of polycystic kidney disease-2-like 1 (PKD2L1)-PKD1L3 complex by acid in mouse taste cells』
Kawaguchi H, Yamanaka A, Uchida K, Shibasaki K, Sokabe T, Maruyama Y, Yanagawa Y, Murakami S, Tominaga M.
J Biol Chem. 2010 Jun 4;285(23):17277-81.

▼doi: 10.1074/jbc.C110.132944. Epub 2010 Apr 20. PMID: 20406802

『Metabolic adaptation of mice in a cool environment』
Uchida K, Shiuchi T, Inada H, Minokoshi Y, Tominaga M.
Pflugers Arch. 2010 Apr;459(5):765-74.

▼doi: 10.1007/s00424-010-0795-3. Epub 2010 Feb 26. PMID: 20186550

『The TRPV4 cation channel mediates stretch-evoked Ca2+ influx and ATP release in primary urothelial cell cultures』
Mochizuki T, Sokabe T, Araki I, Fujishita K, Shibasaki K, Uchida K, Naruse K, Koizumi S, Takeda M, Tominaga M.
J Biol Chem. 2009 Aug 7;284(32):21257-64.

▼doi: 10.1074/jbc.M109.020206. Epub 2009 Jun 15. PMID: 19531473

『Intracellular alkalization causes pain sensation through activation of TRPA1 in mice』
Fujita F, Uchida K, Moriyama T, Shima A, Shibasaki K, Inada H, Sokabe T, Tominaga M.
J Clin Invest. 2008 Dec;118(12):4049-57.

▼doi: 10.1172/JCI35957. Epub 2008 Nov 13. PMID: 19033673

『Design and evaluation of S-nitrosylated human serum albumin as a novel anticancer drug』
Katayama N, Nakajou K, Komori H, Uchida K, Yokoe J, Yasui N, Yamamoto H, Kai T, Sato M, Nakagawa T, Takeya M, Maruyama T, Otagiri M.
J Pharmacol Exp Ther. 2008 Apr;325(1):69-76.

▼doi: 10.1124/jpet.107.132100. Epub 2008 Jan 24. PMID: 18218831

『Fluvoxamine, a selective serotonin reuptake inhibitor, exerts its antiallodynic effects on neuropathic pain in mice via 5-HT2A/2C receptors』
KHonda M, Uchida K, Tanabe M, Ono H.
Neuropharmacology. 2006 Sep;51(4):866-72.

▼doi: 10.1016/j.neuropharm.2006.05.031. Epub 2006 Jul 17. PMID: 16846619