最新の論文
2023年12月7日 共同研究を行った論文が公開されました。
『Canine, mouse, and human transient receptor potential ankyrin 1 (TRPA1) channels show different sensitivity to menthol or cold stimulation』
Takuya Yamaguchi, Kunitoshi Uchida, Jun Yamazaki
J Vet Med Sci. 2023 Dec 6;85(12):1301-1309.
『Transient Receptor Potential Ankyrin 1 in Taste Nerve Contributes to the Sense of Sweet Taste in Mice』
Kenjiro Matsumoto, Mayu Kamide, Kunitoshi Uchida, Mitsuki Takahata, Runa Shichiri, Yuka Hida, Yumi Taniguchi, Akihiro Ohishi, Makoto Tominaga, Kazuki Nagasawa, Shinichi Kato
Biol Pharm Bull. 2023;46(7):939-945.
これまでの論文
『Colonic TRPV4 overexpression is related to constipation severity』
Hiroshi Mihara, Kunitoshi Uchida, Yoshiyuki Watanabe, Sohachi Nanjo, Miho Sakumura, Iori Motoo, Takayuki Ando, Masami Minemura, Jibran Sualeh Muhammad, Hiroyuki Yamamoto, Fumio Itoh, Ichiro Yasuda
BMC Gastroenterol. 2023 Jan 13;23(1):13.
『Involvement of mechano-sensitive Piezo1 channel in the differentiation of brown adipocytes』
Manato Kenmochi, Satoko Kawarasaki, Satsuki Takizawa, Kazuhiko Okamura, Tsuyoshi Goto, Kunitoshi Uchida
J Physiol Sci. 2022 Jun 20;72(1):13.
『Involvement of pore helix in voltage-dependent inactivation of TRPM5 channel』
Kunitoshi Uchida, Tomo Kita, Mitsutoki Hatta, Satoru G. Itoh, Hisashi Okumura, Makoto Tominaga, Jun Yamazaki
Heliyon. 2021 Jan 29;7(1):e06102.
『Intragastric administration of AMG517, a TRPV1 antagonist, enhanced activity-dependent energy metabolism via capsaicin-sensitive sensory nerves in mice』
Jun Hai, Fuminori Kawabata, Kunitoshi Uchida, Shotaro Nishimura, Shoji Tabata
JBiosci Biotechnol Biochem. 2020 Oct;84(10):2121-2127.
『Identification and classification of a new TRPM3 variant (γ subtype)』
Uchida K, Fukuta N, Yamazaki J, Tominaga M.
J Physiol Sci. 2019 Jul;69(4):623-634.
『FK506 (tacrolimus) causes pain sensation through the activation of transient receptor potential ankyrin 1 (TRPA1) channels』
Kita T, Uchida K, Kato K, Suzuki Y, Tominaga M, Yamazaki J.
J Physiol Sci. 2019 Mar;69(2):305-316.
『Sensory nerve supports epithelial stem cell function in healing of corneal epithelium in mice: the role of trigeminal nerve transient receptor potential vanilloid 4』
Okada Y, Sumioka T, Ichikawa K, Sano H, Nambu A, Kobayashi K, Uchida K, Suzuki Y, Tominaga M, Reinach PS, Hirai SI, Jester JV, Miyajima M, Shirai K, Iwanishi H, Kao WW, Liu CY, Saika S.
Lab Invest. 2019 Feb;99(2):210-230.
『Involvement of VNUT-exocytosis in transient receptor potential vanilloid 4-dependent ATP release from gastrointestinal epithelium』
Mihara H, Uchida K, Koizumi S, Moriyama Y.
PLoS One. 2018 Oct 26;13(10):e0206276.
『Role of thermo-sensitive transient receptor potential channels in brown adipose Ttssue』
Uchida K, Sun W, Yamazaki J, Tominaga M.
Biol Pharm Bull. 2018;41(8):1135-1144.
『TRPV2 channel inhibitors attenuate fibroblast differentiation and contraction mediated by keratinocyte-derived TGF-β1 in an in vitro wound healing model of rats』
Ishii T, Uchida K, Hata S, Hatta M, Kita T, Miyake Y, Okamura K, Tamaoki S, Ishikawa H, Yamazaki J.
J Dermatol Sci. 2018 Jun;90(3):332-342.
『Keratin 13 gene is epigenetically suppressed during transforming growth factor-β1-induced epithelial-mesenchymal transition in a human keratinocyte cell line』
Hatta M, Miyake Y, Uchida K, Yamazaki J.
Biochem Biophys Res Commun. 2018 Feb 5;496(2):381-386.
『β-Eudesmol, an oxygenized sesquiterpene, stimulates appetite via TRPA1 and the autonomic nervous system』
Ohara K, Fukuda T, Ishida Y, Takahashi C, Ohya R, Katayama M, Uchida K, Tominaga M, Nagai K.
Sci Rep. 2017 Nov 17;7(1):15785.
『Mouse Anaphylactic Hypotension Is Characterized by Initial Baroreflex Independent Renal Sympathoinhibition Followed by Sustained Renal Sympathoexcitation』
Zhang T, Tanida M, Uchida K, Suzuki Y, Yang W, Kuda Y, Kurata Y, Tominaga M, Shibamoto T.
Front Physiol. 2017 Sep 7;8:669.
『10-oxo-12( Z)-octadecenoic acid, a linoleic acid metabolite produced by gut lactic acid bacteria, enhances energy metabolism by activation of TRPV1』
Kim M, Furuzono T, Yamakuni K, Li Y, Kim YI, Takahashi H, Ohue-Kitano R, Jheng HF, Takahashi N, Kano Y, Yu R, Kishino S, Ogawa J, Uchida K, Yamazaki J, Tominaga M, Kawada T, Goto T.
FASEB J. 2017 Nov;31(11):5036-5048.
『l-Ornithine and l-lysine stimulate gastrointestinal motility via transient receptor potential vanilloid 1』
Nakato J, Ho YY, Omae R, Mizushige T, Uchida K, Tominaga M, Kim M, Goto T, Takahashi N, Kawada T, Akiduki S, Kanamoto R, Ohinata K.
Mol Nutr Food Res. 2017 Nov;61(11).
『Involvement of thermosensitive TRP channels in energy metabolism』
Uchida K, Dezaki K, Yoneshiro T, Watanabe T, Yamazaki J, Saito M, Yada T, Tominaga M, Iwasaki Y.
J Physiol Sci. 2017 Sep;67(5):549-560.
『Hypotonicity-induced cell swelling activates TRPA1』
Fujita F, Uchida K, Takayama Y, Suzuki Y, Takaishi M, Tominaga M.
J Physiol Sci. 2018 Jul;68(4):431-440.
『Biphasic renal sympathetic response to hemorrhagic hypotension in mice』
Zhang T, Tanida M, Uchida K, Suzuki Y, Yang W, Kuda Y, Kurata Y, Tominaga M, Shibamoto T.
Shock. 2017 Nov;48(5):576-582.
『Lysophosphatidic acid-induced itch is mediated by signalling of LPA 5 receptor, phospholipase D and TRPA1/TRPV1』
Kittaka H, Uchida K, Fukuta N, Tominaga M.
J Physiol. 2017 Apr 15;595(8):2681-2698.
『TRPV2 regulates BAT thermogenesis and differentiation』
Sun W, Uchida K, Tominaga M.
Channels (Austin). 2017 Mar 4;11(2):94-96.
『Activation of TRPV2 negatively regulates the differentiation of mouse brown adipocytes』
Sun W, Uchida K, Takahashi N, Iwata Y, Wakabayashi S, Goto T, Kawada T, Tominaga M.
Pflugers Arch. 2016 Sep;468(9):1527-40.
『TRPM3 gating in planar lipid bilayers defines peculiar agonist specificity』
Demirkhanyan L, Uchida K, Tominaga M, Zakharian E.
Channels (Austin). 2016 Jul 3;10(4):258-60.
『Lack of TRPV2 impairs thermogenesis in mouse brown adipose tissue』
Sun W, Uchida K, Suzuki Y, Zhou Y, Kim M, Takayama Y, Takahashi N, Goto T, Wakabayashi S, Kawada T, Iwata Y, Tominaga M.
EMBO Rep. 2016 Mar;17(3):383-99.
『Fish oil intake induces UCP1 upregulation in brown and white adipose tissue via the sympathetic nervous system』
Kim M, Goto T, Yu R, Uchida K, Tominaga M, Kano Y, Takahashi N, Kawada T.
Sci Rep. 2015 Dec 17;5:18013.
『Stimulation-dependent gating of TRPM3 channel in planar lipid bilayers』
Uchida K, Demirkhanyan L, Asuthkar S, Cohen A, Tominaga M, Zakharian E.
FASEB J. 2016 Mar;30(3):1306-16.
『Reciprocal effects of capsaicin and menthol on thermosensation through regulated activities of TRPV1 and TRPM8』
Takaishi M, Uchida K, Suzuki Y, Matsui H, Shimada T, Fujita F, Tominaga M.
J Physiol Sci. 2016 Mar;66(2):143-55.
『TRPM7 protein contributes to intercellular junction formation in mouse urothelium』
Watanabe M, Suzuki Y, Uchida K, Miyazaki N, Murata K, Matsumoto S, Kakizaki H, Tominaga M.
J Biol Chem. 2015 Dec 11;290(50):29882-92.
『TRPM2, a susceptibility gene for bipolar disorder, regulates glycogen synthase kinase-3 activity in the brain』
Jang Y, Lee SH, Lee B, Jung S, Khalid A, Uchida K, Tominaga M, Jeon D, Oh U.
J Neurosci. 2015 Aug 26;35(34):11811-23.
『Identification of significant amino acids in multiple transmembrane domains of human transient receptor potential ankyrin 1 (TRPA1) for activation by eudesmol, an oxygenized sesquiterpene in hop essential oil』
Ohara K, Fukuda T, Okada H, Kitao S, Ishida Y, Kato K, Takahashi C, Katayama M, Uchida K, Tominaga M.
J Biol Chem. 2015 Jan 30;290(5):3161-71.
『The role of TRPM2 in pancreatic β-cells and the development of diabetes』
Uchida K, Tominaga M.
Cell Calcium. 2014 Nov;56(5):332-9.
『Involvement of cAMP/EPAC/TRPM2 activation in glucose- and incretin-induced insulin secretion』
Yosida M, Dezaki K, Uchida K, Kodera S, Lam NV, Ito K, Rita RS, Yamada H, Shimomura K, Ishikawa SE, Sugawara H, Kawakami M, Tominaga M, Yada T, Kakei M.
Diabetes. 2014 Oct;63(10):3394-403.
『Activation and inhibition of thermosensitive TRP channels by voacangine, an alkaloid present in Voacanga africana, an African tree』
Yamawaki H, Mihara H, Suzuki N, Nishizono H, Uchida K, Watanabe S, Tominaga M, Sugiyama T.
Am J Physiol Gastrointest Liver Physiol. 2014 Jul 1;307(1):G33-40.
『Role of transient receptor potential vanilloid 4 activation in indomethacin-induced intestinal damage』
Terada Y, Horie S, Takayama H, Uchida K, Tominaga M, Watanabe T.
J Nat Prod. 2014 Feb 28;77(2):285-97.
『Inhibitory effects of monoterpenes on human TRPA1 and the structural basis of their activity』
Takaishi M, Uchida K, Fujita F, Tominaga M.
J Physiol Sci. 2014 Jan;64(1):47-57.
『Identification of a splice variant of mouse TRPA1 that regulates TRPA1 activity』
Zhou Y, Suzuki Y, Uchida K, Tominaga M.
Nat Commun. 2013;4:2399.
『Extracellular zinc ion regulates transient receptor potential melastatin 5 (TRPM5) channel activation through its interaction with a pore loop domain』
Uchida K, Tominaga M.
J Biol Chem. 2013 Sep 6;288(36):25950-5.
『Ambient temperature affects the temperature threshold for TRPM8 activation through interaction of phosphatidylinositol 4,5-bisphosphate』
Fujita F, Uchida K, Takaishi M, Sokabe T, Tominaga M.
J Neurosci. 2013 Apr 3;33(14):6154-9.
『Involvement of TRPA1 activation in acute pain induced by cadmium in mice』
Miura S, Takahashi K, Imagawa T, Uchida K, Saito S, Tominaga M, Ohta T.
Mol Pain. 2013 Feb 28;9:7.
『TRPM2 contributes to antigen-stimulated Ca?? influx in mucosal mast cells』
Oda S, Uchida K, Wang X, Lee J, Shimada Y, Tominaga M, Kadowaki M.
Pflugers Arch. 2013 Jul;465(7):1023-30.
『1,8-cineole, a TRPM8 agonist, is a novel natural antagonist of human TRPA1』
Takaishi M, Fujita F, Uchida K, Yamamoto S, Sawada Shimizu M, Hatai Uotsu C, Shimizu M, Tominaga M.
Mol Pain. 2012 Nov 29;8:86.
『Isothiocyanates from Wasabia japonica activate transient receptor potential ankyrin 1 channel』
Uchida K, Miura Y, Nagai M, Tominaga M.
Chem Senses. 2012 Nov;37(9):809-18.
『Primary alcohols activate human TRPA1 channel in a carbon chain length-dependent manner』
Komatsu T, Uchida K, Fujita F, Zhou Y, Tominaga M.
Pflugers Arch. 2012 Apr;463(4):549-59.
『Activation of transient receptor potential A1 by a non-pungent capsaicin-like compound, capsiate』
Shintaku K, Uchida K, Suzuki Y, Zhou Y, Fushiki T, Watanabe T, Yazawa S, Tominaga M.
Br J Pharmacol. 2012 Mar;165(5):1476-86.
『The role of thermosensitive TRP (transient receptor potential) channels in insulin secretion』
Uchida K, Tominaga M.
Endocr J. 2011;58(12):1021-8.
『TRPM2 modulates insulin secretion in pancreatic β-cells』
Uchida K, Tominaga M.
Islets. Jul-Aug 2011;3(4):209-11.
『Hypoxia-induced sensitization of transient receptor potential vanilloid 1 involves activation of hypoxia-inducible factor-1 alpha and PKC』
Ristoiu V, Shibasaki K, Uchida K, Zhou Y, Ton BH, Flonta ML, Tominaga M.
Pain. 2011 Apr;152(4):936-45.
『Unusual pungency from extra-virgin olive oil is attributable to restricted spatial expression of the receptor of oleocanthal』
Peyrot des Gachons C, Uchida K, Bryant B, Shima A, Sperry JB, Dankulich-Nagrudny L, Tominaga M, Smith AB 3rd, Beauchamp GK, Breslin PA.
J Neurosci. 2011 Jan 19;31(3):999-1009.
『Lack of TRPM2 impaired insulin secretion and glucose metabolisms in mice』
Uchida K, Dezaki K, Damdindorj B, Inada H, Shiuchi T, Mori Y, Yada T, Minokoshi Y, Tominaga M.
Diabetes. 2011 Jan;60(1):119-26.
『Activation of polycystic kidney disease-2-like 1 (PKD2L1)-PKD1L3 complex by acid in mouse taste cells』
Kawaguchi H, Yamanaka A, Uchida K, Shibasaki K, Sokabe T, Maruyama Y, Yanagawa Y, Murakami S, Tominaga M.
J Biol Chem. 2010 Jun 4;285(23):17277-81.
『Metabolic adaptation of mice in a cool environment』
Uchida K, Shiuchi T, Inada H, Minokoshi Y, Tominaga M.
Pflugers Arch. 2010 Apr;459(5):765-74.
『The TRPV4 cation channel mediates stretch-evoked Ca2+ influx and ATP release in primary urothelial cell cultures』
Mochizuki T, Sokabe T, Araki I, Fujishita K, Shibasaki K, Uchida K, Naruse K, Koizumi S, Takeda M, Tominaga M.
J Biol Chem. 2009 Aug 7;284(32):21257-64.
『Intracellular alkalization causes pain sensation through activation of TRPA1 in mice』
Fujita F, Uchida K, Moriyama T, Shima A, Shibasaki K, Inada H, Sokabe T, Tominaga M.
J Clin Invest. 2008 Dec;118(12):4049-57.
『Design and evaluation of S-nitrosylated human serum albumin as a novel anticancer drug』
Katayama N, Nakajou K, Komori H, Uchida K, Yokoe J, Yasui N, Yamamoto H, Kai T, Sato M, Nakagawa T, Takeya M, Maruyama T, Otagiri M.
J Pharmacol Exp Ther. 2008 Apr;325(1):69-76.
『Fluvoxamine, a selective serotonin reuptake inhibitor, exerts its antiallodynic effects on neuropathic pain in mice via 5-HT2A/2C receptors』
KHonda M, Uchida K, Tanabe M, Ono H.
Neuropharmacology. 2006 Sep;51(4):866-72.
